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首页> Molecular and cellular neurosciences> C-terminal binding proteins are essential pro-survival factors that undergo caspase-dependent downregulation during neuronal apoptosis.

C-terminal binding proteins are essential pro-survival factors that undergo caspase-dependent downregulation during neuronal apoptosis.

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作者： Trisha R,Stankiewicz ^[1] ; Emily K,Schroeder ^[2] ; Natalie A,Kelsey ^[1] ; Ron J,Bouchard ^[2] ; Daniel A,Linseman ^[1]

作者单位： Research Service, Veterans Affairs Medical Center, Denver, Colorado, 80220, USA. ^[1] Department of Biological Sciences and Eleanor Roosevelt Institute, University of Denver, Denver, Colorado, 80208, USA. ^[2] Division of Clinical Pharmacology and Toxicology, Department of Medicine and Neuroscience Program, University of Colorado School of Medicine, Aurora, Colorado, 80045, USA. ^[3]

关键词 4,6-diamidino-2-phenylidole 4-methylthio-2-oxobutyric 6-OHDA 6-hydroxydopamine AD Anti B-cell lymphoma-3 BKLF Bcl-3 C-terminal binding protein C-terminal binding proteins (CtBPs)CCD CGNs Caspase-3 Con CtBP DAPI DGCR8 DiGeorge critical region 8 EP G protein-coupled receptor kinase-interacting protein-z-short GITz-short Inv KO LTox MEFs MPP(+)MTOB Neuronal apoptosis PARP PBS PCR RNA silencing suppressor RSS SNP STS Tox B Toxin B WT actinomycin D basic Krüppel-like factor cerebellar granule neurons charge-coupled device control dCtBP drosophila CtBP endoporter inverse knockout lethal toxin mESCs methyl-4-phenylpyridinium miRNA micro RNA morpholino-antisense oligonucleotides mouse embryonic stem cells murine embryonic fibroblasts phosphate buffer saline poly-(ADP-ribose) polymerase polymerase chain reaction rCasp3 recombinant caspase-3 sodium nitroprusside staurosporine wild type

主题词动物(Animals);细胞凋亡(Apoptosis);载体蛋白质类(Carrier Proteins);半胱氨酸天冬氨酸蛋白酶3(Caspase 3);减量调节(Down-Regulation);女(雌)性(Female);男(雄)性(Male);甲硫氨酸(Methionine);神经元(Neurons);钾(Potassium);原癌基因蛋白质c-bcl-2(Proto-Oncogene Proteins c-bcl-2);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);星状孢子素(Staurosporine);转录因子(Transcription Factors)

DOI 10.1016/j.mcn.2013.07.004

PMID 23859824

发布时间 2021-10-21

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Molecular and cellular neurosciences

322-332页

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