换一批Hmgb1 can facilitate activation of the matrilin-1 gene promoter by Sox9 and L-Sox5/Sox6 in early steps of chondrogenesis.
第一作者：
Tibor,Szénási
第一单位：
Institute of Biochemistry, Biological Research Centre, Hungarian Academy of Sciences, H-6701 Szeged, Hungary. Electronic address: sztibor@brc.hu.
作者：
关键词
CECCEFCartilage-specific regulationChIPChromatin immunoprecipitationDpe1 and Dpe2ECMEMSAGPGSTGrowth plateHDMHMGHMG boxHmgbIneLDMLM-PCRMatrilinNfiPe1RCSSI and SIISilencingTransgenic micechicken embryo chondrocytechicken embryo fibroblastchromatin immunoprecipitationdistal promoter upstream elements 1 and 2electrophoretic mobility shift assayextracellular matrixglutathione S-transferasegrowth platehigh density mesenchymehigh-mobility-groupinitiator elementligation-mediated PCRlow density mesenchymenuclear factor Ipromoter element 1rat chondrosarcomasilencer elements I and II
医学主题词
动物(Animals);结合部位(Binding Sites);印迹法, 蛋白质(Blotting, Western);COS细胞(COS Cells);细胞, 培养的(Cells, Cultured);鸡胚(Chick Embryo);软骨细胞(Chondrocytes);软骨发生(Chondrogenesis);染色质免疫沉淀法(Chromatin Immunoprecipitation);电泳迁移位移试验(Electrophoretic Mobility Shift Assay);荧光抗体技术(Fluorescent Antibody Technique);HMGB1蛋白质(HMGB1 Protein);人类(Humans);中胚层(Mesoderm);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 近交CBA(Mice, Inbred CBA);小鼠, 转基因(Mice, Transgenic);启动区, 遗传(Promoter Regions, Genetic);RNA, 信使(RNA, Messenger);大鼠(Rats);反应元件(Response Elements);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);SOX9转录因子类(SOX9 Transcription Factor);SOXD转录因子类(SOXD Transcription Factors)
DOI
10.1016/j.bbagrm.2013.07.004
PMID
23860260
发布时间
2019-12-10
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