Crystal structure of 3-hydroxybenzoate 6-hydroxylase uncovers lipid-assisted flavoprotein strategy for regioselective aromatic hydroxylation.

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第一作者： Stefania,Montersino

第一单位： From the Laboratory of Biochemistry, Wageningen University, 6703 HA Wageningen, The Netherlands.

作者： Stefania,Montersino ^[1] ; Roberto,Orru ^[2] ; Arjan,Barendregt ^[3] ; Adrie H,Westphal ^[1] ; Esther,van Duijn ^[3] ; Andrea,Mattevi ^[4] ; Willem J H,van Berkel ^[5]

作者单位： From the Laboratory of Biochemistry, Wageningen University, 6703 HA Wageningen, The Netherlands. ^[1] Department of Biology and Biotechnology, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy, and. ^[2] Biomolecular Mass Spectrometry and Proteomics, Bijvoet Center for Biomolecular Research, and Utrecht Institute for Pharmaceutical Sciences, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands. ^[3] Department of Biology and Biotechnology, University of Pavia, Via Ferrata 9, 27100 Pavia, Italy, and. Electronic address: andrea.mattevi@unipv.it. ^[4] From the Laboratory of Biochemistry, Wageningen University, 6703 HA Wageningen, The Netherlands,. Electronic address: willem.vanberkel@wur.nl. ^[5]

关键词 Crystal Structure Flavoproteins Gentisate Hydroxylase Monooxygenase Oxidation-Reduction Phospholipid Rhodococcus