Pro-inflammatory cytokines negatively regulate PPARγ mediated gene expression in both human and murine macrophages via multiple mechanisms.
作者:
关键词
AdrpArgBMDMCytokineFABPFizz1GAPDHIFNILInflammationMHC-related proteinMRMacrophageNuclear receptorPPARRSGSTATTNFTranscriptionYm-1adipose differentiation-related proteinarginasebone marrow derived macrophagechitinase 3-like 3fatty acid binding proteinfound in inflammatory zone, also known as RELM-αor resistin-like molecule-αglyceraldehyde 3-phosphate dehydrogenaseiNOSinducible nitric oxide synthaseinterferoninterleukinoxLDLoxidized low density lipoproteinperoxisome proliferator-activated receptorrosiglitazonesignal transducer and activator of transcriptiontumor necrosis factor
主题词
动物(Animals);抗原, CD34(Antigens, CD34);骨髓细胞(Bone Marrow Cells);细胞分化(Cell Differentiation);细胞, 培养的(Cells, Cultured);DNA(DNA);DNA结合蛋白质类(DNA-Binding Proteins);脂肪酸结合蛋白质类(Fatty Acid-Binding Proteins);基因表达(Gene Expression);基因表达调控(Gene Expression Regulation);人类(Humans);炎症(Inflammation);干扰素γ(Interferon-gamma);白细胞介素4(Interleukin-4);脂类代谢(Lipid Metabolism);巨噬细胞(Macrophages);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);PPARγ(PPAR gamma);STAT6转录因子(STAT6 Transcription Factor);信号传导(Signal Transduction);干细胞(Stem Cells);转录激活(Transcriptional Activation);肿瘤坏死因子α(Tumor Necrosis Factor-alpha)
DOI
10.1016/j.imbio.2013.06.011
PMID
23870825
发布时间
2017-11-16
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Immunobiology
1336-44页
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