BMN 673, a novel and highly potent PARP1/2 inhibitor for the treatment of human cancers with DNA repair deficiency.
作者:
主题词
动物(Animals);印迹法, 蛋白质(Blotting, Western);乳腺肿瘤(Breast Neoplasms);细胞增殖(Cell Proliferation);DNA修复缺陷相关疾病(DNA Repair-Deficiency Disorders);抗药性, 肿瘤(Drug Resistance, Neoplasm);女(雌)性(Female);流式细胞术(Flow Cytometry);人类(Humans);小鼠(Mice);小鼠, 裸(Mice, Nude);酞嗪类(Phthalazines);聚ADP核糖聚合酶类(Poly(ADP-ribose) Polymerases);RNA, 小分子干扰(RNA, Small Interfering);大鼠(Rats);肿瘤细胞, 培养的(Tumor Cells, Cultured);肿瘤干细胞测定(Tumor Stem Cell Assay);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1158/1078-0432.CCR-13-1391
PMID
23881923
发布时间
2024-02-10
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Clinical cancer research
5003-15页
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