A positive role of mammalian Tip41-like protein, TIPRL, in the amino-acid dependent mTORC1-signaling pathway through interaction with PP2A.
第一作者:
Akio,Nakashima
第一单位:
Biosignal Research Center, Kobe University, Kobe 657-8501, Japan.
作者:
关键词
4E-BP1Amino acidHAHCCPP2APP2A catalytic subunitPP2AcS6K1TIPRLTORTOR complexTORCTRAILTap42Tap42-interacting protein of 41kDaTip41eIF4E-binding protein 1hemagglutininhepatocellular carcinomamTORmTORC1mechanistic TORp70 ribosomal protein S6 kinase 1protein phosphatase 2AsiRNAsmall interfering RNAtarget of rapamycintarget of rapamycin signaling pathway regulator-liketumor necrosis factor-related apoptosis-inducing ligandtype 2A phosphatase-associated protein of 42kDa
主题词
动物(Animals);细胞系(Cell Line);基因表达调控(Gene Expression Regulation);人类(Humans);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);小鼠(Mice);多蛋白复合物(Multiprotein Complexes);点突变(Point Mutation);蛋白质磷酸酶2(Protein Phosphatase 2);RNA, 小分子干扰(RNA, Small Interfering);大鼠(Rats);信号传导(Signal Transduction);TOR丝氨酸-苏氨酸激酶(TOR Serine-Threonine Kinases);转染(Transfection)
DOI
10.1016/j.febslet.2013.07.027
PMID
23892082
发布时间
2021-12-03
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FEBS letters
2924-9页
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