换一批Berberine ameliorates experimental diabetes-induced renal inflammation and fibronectin by inhibiting the activation of RhoA/ROCK signaling.
第一作者：
Xi,Xie
第一单位：
Laboratory of Pharmacology & Toxicology, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China; Department of Pharmaceutical Engineering, Ocean College, Hainan University, Haikou 570228, China.
作者：
关键词
BerberineDNDiabetic nephropathyECMFibronectinGMCsICAM-1MDAMYPTN-acetylcysteineNACNF-κBROCKROSRhoA/ROCKSODSTZTGF-β1diabetic nephropathyextracellular matrixglomerular mesangial cellsintercellular adhesionmolecule-1malondialdehydemyosin phosphatasenuclear factor-kappa Breactive oxygen speciesrho kinasestreptozocinsuperoxide dismutasetransforming growth factor-beta 1
医学主题词
乙酰半胱氨酸(Acetylcysteine);主动转运, 细胞核(Active Transport, Cell Nucleus);动物(Animals);消炎药(Anti-Inflammatory Agents);小檗碱(Berberine);细胞, 培养的(Cells, Cultured);糖尿病, 实验性(Diabetes Mellitus, Experimental);药物评价, 临床前(Drug Evaluation, Preclinical);纤连蛋白类(Fibronectins);自由基清除剂(Free Radical Scavengers);基因表达(Gene Expression);胞间黏附分子1(Intercellular Adhesion Molecule-1);肾(Kidney);男(雄)性(Male);肾小球系膜细胞(Mesangial Cells);NF-κB(NF-kappa B);肾炎(Nephritis);氧化性应激(Oxidative Stress);蛋白质结合(Protein Binding);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);信号传导(Signal Transduction);转化生长因子β1(Transforming Growth Factor beta1);rho相关激酶类(rho-Associated Kinases);ρA GTP结合蛋白质(rhoA GTP-Binding Protein)
DOI
10.1016/j.mce.2013.07.019
PMID
23896433
发布时间
2013-10-07
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