换一批
换一批Synthesis and broad spectrum antiviral evaluation of bis(POM) prodrugs of novel acyclic nucleosides.
第一作者：
Manabu,Hamada
第一单位：
Institut de Chimie Organique et Analytique, UMR 7311 CNRS, Université d'Orléans, 45067 Orléans, France.
作者：
关键词
Antiviral propertiesCC(50)DNAEC(50)HSVMCCMDCKMadin–Darby canine kidneyModified heterocyclesNucleosidesOlefin cross metathesisRNASynthesisVSVVVVZVcompound concentration affording 50 inhibition of cell growthcompound concentration affording 50 inhibition of the viral cytopathicitydeoxyribonucleic acidherpes simplex virusminimum cytotoxic concentration required to afford a microscopically detectable alteration of cell morphologyribonucleic acidvaccinia virusvaricella zoster virusvesicular stomatitis virus
主题词
抗病毒药(Antiviral Agents);细胞, 培养的(Cells, Cultured);剂量效应关系, 药物(Dose-Response Relationship, Drug);人类(Humans);微生物敏感性试验(Microbial Sensitivity Tests);分子结构(Molecular Structure);核苷类(Nucleosides);药物前体(Prodrugs);构效关系(Structure-Activity Relationship);病毒(Viruses)
DOI
10.1016/j.ejmech.2013.06.053
PMID
23911854
发布时间
2022-02-16
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