Nerve growth factor acts through the TrkA receptor to protect sensory neurons from the damaging effects of the HIV-1 viral protein, Vpr.
第一作者:
C A,Webber
第一单位:
Division of Anatomy, University of Alberta, Edmonton, Alberta T6G 2H7, Canada. Electronic address: webber2@ualberta.ca.
作者:
关键词
1-β-d-arabinofuranosylcytosineACSFAIDSANOVAAraCDMEM/F12DRGDSPDulbecco’s Modified Eagle’s Medium/Ham’s F-12EDTAGSK3βHAARTHIVNGFPBSTrkAVpracquired immunodeficiency syndromeanalysis of varianceartificial cerebral spinal fluiddistal sensory polyneuropathydorsal root ganglionethylenediaminetetraacetic acidglycogen synthase kinase-3 betahighly active antiretroviral therapyhuman immunodeficiency virushuman immunodeficiency virus (HIV)nerve growth factornerve growth factor (NGF)neuropathic painpGSK3βphosphate-buffered salinephosphorylated GSK3βqRT-PCRquantitative real-time polymerase chain reactiontropomyosin-related kinase Atropomyosin-related kinase A (TrkA)viral protein Rviral protein R (Vpr)
主题词
获得性免疫缺陷综合征(Acquired Immunodeficiency Syndrome);动物(Animals);印迹法, 蛋白质(Blotting, Western);细胞, 培养的(Cells, Cultured);胎儿(Fetus);荧光抗体技术(Fluorescent Antibody Technique);神经节, 脊(Ganglia, Spinal);HIV感染(HIV Infections);人类(Humans);免疫组织化学(Immunohistochemistry);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);神经生长因子(Nerve Growth Factor);神经痛(Neuralgia);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, trkA(Receptor, trkA);感觉感受器细胞(Sensory Receptor Cells);信号传导(Signal Transduction);vpr基因产物, 人免疫缺陷病毒(vpr Gene Products, Human Immunodeficiency Virus)
DOI
10.1016/j.neuroscience.2013.07.046
PMID
23912036
发布时间
2021-10-21
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Neuroscience
512-25页
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