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    首页> Neuropharmacology> 2-Guanidine-4-methylquinazoline acts as a novel competitive antagonist of A type γ-aminobutyric acid receptors.

    2-Guanidine-4-methylquinazoline acts as a novel competitive antagonist of A type γ-aminobutyric acid receptors.

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    作者： Xian,Xiao [1] ; Michael X,Zhu [2] ; Tian-Le,Xu [3]
    作者单位： Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Department of Anatomy and Embryology, Shanghai Key Laboratory for Reproductive Medicine, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. [1] Department of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, Houston, TX 77030, USA. [2] Department of Anatomy and Embryology, Shanghai Key Laboratory for Reproductive Medicine, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Department of Biochemistry and Molecular Cell Biology, Shanghai Key Laboratory for Tumor Microenvironment and Inflammation, Institute of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Electronic address: xu-happiness@shsmu.edu.cn. [3]
    关键词 2-guanidine-4-methylquinazoline6-cyano-7-nitroquinoxaline-2,3-dioneA type γ-aminobutyric acid receptorACSFAChAMPARASICBicCNQXCompetitive antagonistD(?)-2-amino-5-phosphonopentanoic acidD-AP5DMEMDRDulbecco's Modified Eagle's MediumGABAGABA(A) receptorGABA(A)RGLICGMQGloeobacter ligand-gated ion channelHBSSHEPESHank's Buffered Salt SolutionI-VN-hydroxyethylpiperazine-N-2-ethanesulphonic acidN-methyl-D-aspartic acid receptorNMDARPSTTXacetylcholineacid-sensing ion channelartificial cerebrospinal fluidbicuculline-methobromidecurrent-voltagedose ratiofEPSPsfield excitatory postsynaptic potentialsmIPSCminiature inhibitory postsynaptic currentnAChRnicotinic acetylcholine receptorpopulation spiketetrodotoxinα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptorγ-aminobutyric acid
    主题词 乙酰胆碱(Acetylcholine);动作电位(Action Potentials);动物(Animals);细胞, 培养的(Cells, Cultured);剂量效应关系, 药物(Dose-Response Relationship, Drug);胚胎, 哺乳动物(Embryo, Mammalian);兴奋性氨基酸药(Excitatory Amino Acid Agents);GABA类药(GABA Agents);甘氨酸(Glycine);胍类(Guanidines);海马(Hippocampus);人类(Humans);突变(Mutation);神经元(Neurons);蛋白质亚单位(Protein Subunits);喹唑啉类(Quinazolines);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, GABA-A(Receptors, GABA-A);γ氨基丁酸(gamma-Aminobutyric Acid)
    DOI 10.1016/j.neuropharm.2013.07.018
    PMID 23916476
    发布时间 2014-11-20
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