换一批
换一批Are endosomal trafficking parameters better targets for improving mAb pharmacokinetics than FcRn binding affinity?
作者：
关键词
DaDaltonsEndosomeF(ab’)(2)FabFcFcRnHalf-lifeIgGK(D)MWModellingMonoclonal antibodyNeonatal Fc receptorPBPKPharmacokineticsSPRTraffickingbinding ratecovalently bound Fab portions of an antibodydissociation rateequilibrium binding affinityfragment crystallisable (antibody constant region)fragment with antigen binding (antibody variable region)immunoglobulin Ginternalisation ratek(int)k(off)k(on)k(rec)kDakilo DaltonsmAbmicrometermicromolarmolecular weightmonoclonal antibodynMnanometernanomolarnegative log(10)concentration of solvated hydrogen ions/acidityneonatal Fc receptornmpHphysiologically based pharmacokineticsrecycling ratesurface plasmon resonanceμMμm
主题词
抗体, 单克隆(Antibodies, Monoclonal);抗体亲和力(Antibody Affinity);结合, 竞争性(Binding, Competitive);内颗粒(Endosomes);组织相容性抗原Ⅰ类(Histocompatibility Antigens Class I);人类(Humans);免疫球蛋白G(Immunoglobulin G);模型, 免疫学(Models, Immunological);蛋白质结合(Protein Binding);蛋白质转运(Protein Transport);受体, Fc(Receptors, Fc)
DOI
10.1016/j.molimm.2013.05.008
PMID
23917469
发布时间
2018-12-02
- 浏览130
Molecular immunology
660-74页
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