Alertness and psychomotor performance effects of the histamine-3 inverse agonist MK-0249 in obstructive sleep apnea patients on continuous positive airway pressure therapy with excessive daytime sleepiness: a randomized adaptive crossover study.

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作者： W Joseph,Herring ^[1] ; Kenneth,Liu ; Jill,Hutzelmann ; Duane,Snavely ; Ellen,Snyder ; Paulette,Ceesay ; Christopher,Lines ; David,Michelson ; Thomas,Roth

作者单位： Merck Sharp and Dohme Corp., Whitehouse Station, NJ, USA. Electronic address: william.herring@merck.com. ^[1]

关键词 Excessive daytime sleepiness Histamine subtype-3 receptor MK-0249 Modafinil Obstructive sleep apnea Randomized trial

主题词青少年(Adolescent);成年人(Adult);二苯甲基化合物(Benzhydryl Compounds);综合疗法(Combined Modality Therapy);连续气道正压通气(Continuous Positive Airway Pressure);交叉研究(Cross-Over Studies);过度嗜睡性障碍(Disorders of Excessive Somnolence);双盲法(Double-Blind Method);女(雌)性(Female);组胺激动药(Histamine Agonists);人类(Humans);男(雄)性(Male);中年人(Middle Aged);精神运动性行为(Psychomotor Performance);喹唑啉酮类(Quinazolinones);睡眠呼吸暂停,阻塞性(Sleep Apnea, Obstructive);治疗结果(Treatment Outcome);觉醒状态(Wakefulness);青年人(Young Adult)

DOI 10.1016/j.sleep.2013.04.010

PMID 23920422

发布时间 2018-12-02

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Sleep medicine

2013年14卷10期

955-63页

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Alertness and psychomotor performance effects of the histamine-3 inverse agonist MK-0249 in obstructive sleep apnea patients on continuous positive airway pressure therapy with excessive daytime sleepiness: a randomized adaptive crossover study.

Sleep medicine

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Sleep medicine

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Alertness and psychomotor performance effects of the histamine-3 inverse agonist MK-0249 in obstructive sleep apnea patients on continuous positive airway pressure therapy with excessive daytime sleepiness: a randomized adaptive crossover study.

Sleep medicine

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Sleep medicine

相关期刊

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