换一批
换一批Methionine restriction prevents the progression of hepatic steatosis in leptin-deficient obese mice.
第一作者：
Virginia L,Malloy
第一单位：
Orentreich Foundation for the Advancement of Science, Inc., 855 Route 301, Cold Spring-on-Hudson, NY 10516, USA. Electronic address: vmalloy@orentreich.org.
作者：
关键词
ALTASTAcacAcadvlAdiponectinApoBC-C chemokine receptor-2CFCcr2Cd 36ChrebpCpt1aDgatEGF-like module-containing mucin-like hormone receptor-like 1Emr1FAOFFAFasnFatty acid oxidationFatty liverGSHGpamHDLHFDHMWHOMAHadha and HadhbIL6IRInflammationItgaxLDLLxrMRMttpNAFLDNASHPklrPnpla2Pnpla3PparαPparγROSScd1Srebf1TGTNF-αTriglycerideVLDLacetyl-CoA carboxylaseacyl-coenzyme A dehydrogenase, very long chainalanine aminotransferaseapolipoprotein Baspartate aminotransferasecarbohydrate regulatory binding proteincarnitine palmitoyltransferase-1acontrol-feddiacylglycerol O-acyltransferasefatty acid oxidationfatty acid synthasefree fatty acidsglutathionehepatic CD36 antigenhigh-density lipoproteinhigh-fat diethigh-molecular-weighthomeostasis model assessmenthydroxyacyl-coenzyme A dehydrogenase/3-ketoacyl-coenzyme A thiolase/enoyl-coenzyme A hydratase (trifunctional protein), alpha and beta subunits, respectivelyinsulin resistanceintegrin alpha Xinterleukin-6liver X-receptorlow-density lipoproteinmethionine restrictionmicrosomal triglyceride transfer proteinmitochondrial glycerol-3-phosphate acyltransferasenon-alcoholic fatty liver diseasenon-alcoholic steatohepatitisob/obobese mousepatatin-like phospholipase domain containing 2patatin-like phospholipase domain containing 3peroxisome proliferator-activated receptor αperoxisome proliferator-activated receptor γpyruvate kinase-liver and red blood cellreactive oxygen speciesstearoyl-coenzyme A desaturase-1sterol regulatory element binding transcription factor 1triglyceridestumor necrosis factor-αvery-low-density lipoprotein
主题词
3-羟基丁酸(3-Hydroxybutyric Acid);动物(Animals);血糖(Blood Glucose);膳食(Diet);疾病恶化(Disease Progression);脂肪酸类(Fatty Acids);脂肪肝(Fatty Liver);基因表达调控(Gene Expression Regulation);内环境稳定(Homeostasis);炎症(Inflammation);胰岛素(Insulin);瘦素(Leptin);脂类代谢(Lipid Metabolism);脂蛋白类, VLDL(Lipoproteins, VLDL);肝(Liver);男(雄)性(Male);甲硫氨酸(Methionine);小鼠(Mice);小鼠, 肥胖(Mice, Obese);肥胖症(Obesity);氧化还原(Oxidation-Reduction);疾病严重程度指数(Severity of Illness Index);甘油三酯类(Triglycerides)
DOI
10.1016/j.metabol.2013.06.012
PMID
23928105
发布时间
2015-11-19
- 浏览157
Metabolism
1651-61页
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