换一批Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration.
第一作者：
Amr S,Abu Lila
第一单位：
Department of Pharmacokinetics and Biopharmaceutics, Subdivision of Biopharmaceutical Sciences, Institute of Health Biosciences, The University of Tokushima, 1-78-1, Sho-machi, Tokushima 770-8505, Japan; Department of Pharmaceutics and Industrial Pharmacy, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
作者：
关键词
(3)H-CHE(3)1,2-distearoyl-sn-glycero-3-phosphoethanolamine-n-[methoxy(polyethylene glycol)-2000]1,2-distearoyl-sn-glycero-3-phosphoethanolamine-n-[polyglycerine-(610, 760, 1500 or 2980)]ABCAUCAccelerated blood clearance (ABC) phenomenonAnti-PEG IgMCHOLDMEMDXRDulbecco's modified Eagle's mediumELISAFBSH-cholesterylhexadecyl etherHEPCHRPMPSPEGPGPG(610, 760, 1500 or 2980)-DSPEPLPolyethylene glycol (PEG)Polyglycerine (PG)Repeated administrationaccelerated blood clearancearea under the blood concentration–time curvecholesteroldoxorubicinenzyme-linked immunosorbent assayfetal bovine serumhorseradish peroxidasehydrogenated egg phosphatidylcholinemPEG(2000)-DSPEmononuclear phagocyte systemphospholipidpolyethylene glycolpolyglycerine
医学主题词
动物(Animals);抗肿瘤药(Antineoplastic Agents);癌, Lewis肺(Carcinoma, Lewis Lung);细胞系, 肿瘤(Cell Line, Tumor);多柔比星(Doxorubicin);甘油(Glycerol);免疫球蛋白M(Immunoglobulin M);脂质体(Liposomes);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);磷脂酰乙醇胺类(Phosphatidylethanolamines);聚乙烯二醇类(Polyethylene Glycols);聚合物(Polymers);大鼠(Rats);大鼠, Wistar(Rats, Wistar);肿瘤负荷(Tumor Burden)
DOI
10.1016/j.ijpharm.2013.07.059
PMID
23928149
发布时间
2018-12-02
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