换一批A novel flavonoid C-glucoside from Ulmus wallichiana preserves bone mineral density, microarchitecture and biomechanical properties in the presence of glucocorticoid by promoting osteoblast survival: a comparative study with human parathyroid hormone.
第一作者：
M P,Khan
第一单位：
Division of Endocrinology, CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226021, India; Center for Research on Anabolic Skeletal Targets in Health and Illness (ASTHI), CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226021, India; Center for Drug Discovery and Development in Reproductive Health (CDDDRH), CSIR-Central Drug Research Institute, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226021, India.
作者：
关键词
6-C-β-d-glucopyranosyl-(2S,3S)-(+)-5,7,3′,4′- tetrahydroxydihydroflavonolAKT pathwayB.ArBFR/BSBMDBV/TVBone anabolicBone histomorphometryConn.DCs.ThDADexDoxGRGTDFGlucocorticoid-induced osteoporosisMARMPQuercetinRunx-2SMITFSPTUNELTb.NTb.pfTb.spTb.thbone and mineral densitybone forming rate/bone surfacebone volume/trabecular volumeconnection densitycortical mean cross-sectional areacortical thicknessdegree of anisotropydexamethasonedoxorubicinglucocorticoids receptormethyl prednisolonemicrocomputed tomographymineral appositional raterunt related transcription factor2structure model indexterminal deoxynucleotidyl transferase dUTP nick end labelingtibia-fibular separation pointtrabecular numbertrabecular pattern factortrabecular separationtrabecular thicknessμCT
医学主题词
动物(Animals);细胞凋亡(Apoptosis);骨密度(Bone Density);骨和骨组织(Bone and Bones);女(雌)性(Female);黄酮醇类(Flavonols);糖皮质激素类(Glucocorticoids);葡糖苷类(Glucosides);男(雄)性(Male);间质干细胞(Mesenchymal Stem Cells);成骨细胞(Osteoblasts);骨钙素(Osteocalcin);骨生成(Osteogenesis);骨质疏松(Osteoporosis);甲状旁腺素(Parathyroid Hormone);植物药疗法(Phytotherapy);植物提取物(Plant Extracts);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);肿瘤抑制蛋白质p53(Tumor Suppressor Protein p53);榆属(Ulmus)
DOI
10.1016/j.phymed.2013.07.007
PMID
23928508
发布时间
2018-12-02
- 浏览111
Phytomedicine
1256-66页
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