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Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance.

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第一作者： Annayya R,Aroor

第一单位： Division of Endocrinology, Diabetes and Metabolism, Diabetes Cardiovascular Center, University of Missouri, Columbia, MO, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO, USA.

作者： Annayya R,Aroor ^[1] ; Susan,McKarns ; Vincent G,Demarco ; Guanghong,Jia ; James R,Sowers

作者单位： Division of Endocrinology, Diabetes and Metabolism, Diabetes Cardiovascular Center, University of Missouri, Columbia, MO, USA; Harry S. Truman Memorial Veterans Hospital, Columbia, MO, USA. ^[1]

关键词 (SOD)3 ARBs AT1R Akt Ang II Ang II receptor blockers C-Jun kinase CKD CVB3 CVD CVO DPP-4 ENOS ERK1/2 FFAs FoxP3 GIP GLP-1 GLP-1 receptor GLP-1R Gender HFCS IFN-γ IL-10 IL-6 IRS Immunity Interleukin 10 JNK LPS MTOR NO Obesity PET PI3-K PKC RAAS ROS S6K SNS SOC3-3 T2DM TGF-β TLR-4 TNF-α Toll-like receptor 4 Tregs Uric acid WAT WD Western Diet angiotensin II angiotensin II type 1 receptor cardiovascular disease chronic kidney disease circumventricular organs coxsackievirus B3 cytokine signaling 3 dipetidyl peptidase 4 endothelial nitric oxide synthase extracellular regulated kinases ?forkhead/winged helix transcription factor 3 free fatty acids glucagon like peptide-1 glucose-dependent insulinotrophic peptide high-fructose corn syrup insulin receptor substrate interferon gamma interleukin 6 lipopolysaccharide mammalian target of rapamycin nitric oxide p70 S6 kinase phosphatidylinositol 3 kinase positron emission tomography protein kinase B protein kinase C reactive oxygen species regulatory T cells renin angiotensin aldosterone system superoxide dismutase sympathetic nervous system transforming growth factor beta tumor necrosis factor alpha type 2 diabetes mellitus white adipose tissue

医学主题词适应性免疫(Adaptive Immunity);动物(Animals);心血管系统(Cardiovascular System);糖尿病(Diabetes Mellitus);疾病恶化(Disease Progression);人类(Humans);高血压, 肾性(Hypertension, Renal);炎症(Inflammation);胰岛素(Insulin);胰岛素抗药性(Insulin Resistance);淋巴细胞(Lymphocytes);巨噬细胞(Macrophages);肥胖症(Obesity);绝经前期(Premenopause);受体, 胰岛素(Receptor, Insulin);肾素-血管紧张素系统(Renin-Angiotensin System);性别因素(Sex Factors);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory)

DOI 10.1016/j.metabol.2013.07.001

PMID 23932846

发布时间 2022-04-09

基金项目

R01 HL073101/HL/NHLBI NIH HHS/United States R01 HL107910/HL/NHLBI NIH HHS/United States R01 HL107910-01/HL/NHLBI NIH HHS/United States R01 HL73101-01A/HL/NHLBI NIH HHS/United States

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