Parthenolide inhibits nociception and neurogenic vasodilatation in the trigeminovascular system by targeting the TRPA1 channel.
第一作者:
Serena,Materazzi
第一单位:
Department of Health Sciences, Clinical Pharmacology Unit, University of Florence, Florence, Italy Headache Center, Florence University Hospital, Florence, Italy Department of Chemistry "U. Schiff", University of Florence, Florence, Italy King's College, London, UK Department of Pharmacology, University of Arizona, Tucson, AZ, USA Department of Pharmaceutical Sciences, University of Eastern Piedmont, Novara, Italy Pharmacology Department, Chiesi Farmaceutici SpA, Parma, Italy.
作者:
主题词
动物(Animals);消炎药, 非甾类(Anti-Inflammatory Agents, Non-Steroidal);CHO细胞(CHO Cells);仓鼠亚科(Cricetinae);仓鼠属(Cricetulus);药物释放系统(Drug Delivery Systems);花(Flowers);HEK293细胞(HEK293 Cells);人类(Humans);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 基因敲除(Mice, Knockout);植物提取物(Plant Extracts);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);倍半萜类(Sesquiterpenes);菊蒿(Tanacetum parthenium);瞬时受体电位通道(Transient Receptor Potential Channels);三叉神经节(Trigeminal Ganglion);三叉神经(Trigeminal Nerve);血管舒张(Vasodilation)
DOI
10.1016/j.pain.2013.08.002
PMID
23933184
发布时间
2021-10-21
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