换一批
第一作者：
Hongzhen,Yu
第一单位：
Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
作者：
关键词
2-(4-amidinophenyl)-6-indolecarbamidine dihydrochlorideAPAUC(0–24h)BLC(max)CRCSCellular uptake and transportCsACsDCyclosporine ADAPIEEHBSSHPMC-ASHSHank’s balanced salt solutionLCLODLOQLSOral bioavailabilityP-glycoproteinP-gpPCSPMsRBARh123Soluplus?Supersaturated polymeric micelleSupersaturation degreeT(max)TEMTfVerapapicalarea under the blood drug concentration–time curvebasolateralcoumarin-6 reference solutioncoumarin-6-loaded Cremophor RH40 micellescyclosporine Acyclosporine Dentrapment efficiencyhigh Soluplus? concentrationhydroxypropyl methylcellulose acetate succinatelimit of detectionlimit of quantificationloading contentlow Soluplus? concentrationmaximal blood concentration of the drugphoton correlation spectroscopypolymeric micellesrelative oral bioavailabilityrhodamine 123time taken to reach the maximum blood concentrationtransmission electron microscopytransport fluxverapamil
医学主题词
吸收(Absorption);投药, 口服(Administration, Oral);动物(Animals);生物利用度(Biological Availability);生物转运(Biological Transport);Caco-2细胞(Caco-2 Cells);化学, 药物(Chemistry, Pharmaceutical);香豆素类(Coumarins);环孢菌素(Cyclosporine);药物释放系统(Drug Delivery Systems);流式细胞术(Flow Cytometry);荧光染料(Fluorescent Dyes);人类(Humans);肠吸收(Intestinal Absorption);男(雄)性(Male);微胶粒(Micelles);显微镜检查, 共焦(Microscopy, Confocal);粒子大小(Particle Size);聚合物(Polymers);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);溶解度(Solubility);水(Water)
DOI
10.1016/j.ejpb.2013.08.003
PMID
23954511
发布时间
2022-03-18
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