换一批Three Ca2+ channel inhibitors in combination limit chronic secondary degeneration following neurotrauma.
第一作者：
Donna L,Savigni
第一单位：
Experimental and Regenerative Neurosciences, The University of Western Australia, Crawley, WA 6009, Australia; School of Animal Biology, The University of Western Australia, Crawley, WA 6009, Australia.
作者：
关键词
2-[7-(1H-imidazol-1-yl)-6-nitro-2,3-dioxo-1,2,3,4-tetrahydro quinoxalin-1-yl]acetic acidAMPAATPCa(2+) channel inhibitorsINQLomMyelinMyelin compactionN-methyl-d-aspartic acidNMDANeurotraumaNode/paranode complexOCTONOPCsOxidative stressPBSPFAPTRGCSEMSecondary degenerationTEMVGCCsVisual systemadenosine triphosphatei.p.intraperitoneallylomerizineoligodendrocyte precursor cellsoptic nerveoptical cutting temperatureoxATPoxidised adenosine-triphosphateparaformaldehydepartial transectionphosphate buffered salineretinal ganglion cellstandard error of the meantransmission electron microscopyvoltage-gated calcium channelsα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid
医学主题词
腺苷三磷酸(Adenosine Triphosphate);动物(Animals);碱性螺旋-环-螺旋转录因子类(Basic Helix-Loop-Helix Transcription Factors);钙通道阻滞药(Calcium Channel Blockers);细胞黏附分子, 神经元(Cell Adhesion Molecules, Neuronal);疾病模型, 动物(Disease Models, Animal);复方合剂(Drug Combinations);女(雌)性(Female);磁共振波谱学(Magnetic Resonance Spectroscopy);神经变性(Nerve Degeneration);神经组织蛋白质类(Nerve Tissue Proteins);眼震, 视动性(Nystagmus, Optokinetic);视神经(Optic Nerve);视神经损伤(Optic Nerve Injuries);视乳头水肿(Papilledema);哌嗪类(Piperazines);郎飞结(Ranvier's Nodes);大鼠(Rats);视网膜神经节细胞(Retinal Ganglion Cells);四氢异喹啉类(Tetrahydroisoquinolines);氚(Tritium)
DOI
10.1016/j.neuropharm.2013.07.034
PMID
23958451
发布时间
2015-11-19
- 浏览77
Neuropharmacology
380-90页
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