换一批
换一批IL-4 confers resistance to IL-27-mediated suppression on CD4+ T cells by impairing signal transducer and activator of transcription 1 signaling.
作者：
关键词
APCAllophycocyaninAsthmaHigh concentrations of T(H)2-inducing reagentsIL-27IL-27 receptorIL-27RIL-4Intermediate concentrations of T(H)2-inducing reagentsLow concentrations of T(H)2-inducing reagentsMFIMean fluorescence intensityMemory T(H)2 cellsMemory non-T(H)2 cells, including T(H)1 and T(H)17 cellsNon-T(H)2(m)PEPhosphorylated STATPhycoerythrinQuantitative RT-PCRRecombinant humanRecombinant murineSOCSSTATSignal transducer and activator of transcriptionSmall interfering RNASuppressor of cytokine signalingT(H)2 stabilityT(H)2(hi)T(H)2(int)T(H)2(lo)T(H)2(m)T-betT-box transcription factorpSTATqPCRrhrmsiRNAsignal transducer and activator of transcription 1 signalingsuppressor of cytokine signaling 3
主题词
动物(Animals);哮喘(Asthma);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);细胞, 培养的(Cells, Cultured);人类(Humans);超敏反应, 速发型(Hypersensitivity, Immediate);白细胞介素4(Interleukin-4);白细胞介素类(Interleukins);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);磷酰化(Phosphorylation);STAT1转录因子(STAT1 Transcription Factor);信号传导(Signal Transduction);细胞因子信号转导蛋白抑制因子(Suppressor of Cytokine Signaling Proteins)
DOI
10.1016/j.jaci.2013.06.035
PMID
23958647
发布时间
2022-11-09
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