换一批Matrix-derived combination effect and risk assessment for estragole from basil-containing plant food supplements (PFS).
第一单位：
Division of Toxicology, Wageningen University, Tuinlaan 5, 6703 HE Wageningen, The Netherlands. Electronic address: suzanne.vandenberg@wur.nl.
作者：
关键词
3′-phosphoadenosine-5′-phosphosulfate7-hydroxycoumarin7-hydroxycoumarin sulfate7HC7HCSBMDBMDL(10)Benchmark DoseDMSOE-3′-N(2)-dGuoEstragoleHPLCMOEMargin of ExposureMatrix-derived combination effectN(2)-(trans-isoestragol-3′-y1)-2′-deoxyguanosineNevadensinPAPSPBKPCPPFSPhysiologically based kinetic (PBK) modelingPlant food supplements (PFS)Risk assessmentSULTTFAUDSULC/MSUPLCdimethyl sulfoxidehigh performance liquid chromatographylower confidence limit of the benchmark dose resulting in a 10 extra cancer incidencepentachlorophenolphysiologically based kineticplant food supplementssulfotransferasetrifluoroacetic acidultra liquid chromatography/mass spectrometryultra performance liquid chromatographyunscheduled DNA synthesis
医学主题词
动物(Animals);茴香醚类(Anisoles);化学分馏法(Chemical Fractionation);DNA加合物(DNA Adducts);营养保健品(Dietary Supplements);剂量效应关系, 药物(Dose-Response Relationship, Drug);黄酮类(Flavones);食品安全(Food Safety);肝(Liver);男(雄)性(Male);罗勒(Ocimum basilicum);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);危险性评估(Risk Assessment);磺基转移酶类(Sulfotransferases)
DOI
10.1016/j.fct.2013.08.019
PMID
23959103
发布时间
2021-12-03
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