CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems.

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作者： Zhexue,Wu ^[1] ; Doohyun,Lee ; Jeongmin,Joo ; Jung-Hoon,Shin ; Wonku,Kang ; Sangtaek,Oh ; Do Yup,Lee ; Su-Jun,Lee ; Sung Su,Yea ; Hye Suk,Lee ; Taeho,Lee ; Kwang-Hyeon,Liu

作者单位： College of Pharmacy and Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, South Korea. ^[1]

主题词阿苯达唑(Albendazole);抗蠕虫药(Anthelmintics);芳基烃羟化酶类(Aryl Hydrocarbon Hydroxylases);生物转化(Biotransformation);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);酶测定(Enzyme Assays);酶抑制剂(Enzyme Inhibitors);芬苯达唑(Fenbendazole);人类(Humans);羟基化(Hydroxylation);动力学(Kinetics);肝(Liver);微粒体, 肝(Microsomes, Liver);重组蛋白质类(Recombinant Proteins)

DOI 10.1128/AAC.00843-13

PMID 23959307

发布时间 2021-12-03

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Antimicrobial agents and chemotherapy

2013年57卷11期

5448-56页

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CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems.

Antimicrobial agents and chemotherapy

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Antimicrobial agents and chemotherapy

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CYP2J2 and CYP2C19 are the major enzymes responsible for metabolism of albendazole and fenbendazole in human liver microsomes and recombinant P450 assay systems.

Antimicrobial agents and chemotherapy

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Antimicrobial agents and chemotherapy

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