换一批The nuclear receptors pregnane X receptor and constitutive androstane receptor contribute to the impact of fipronil on hepatic gene expression linked to thyroid hormone metabolism.
第一作者：
Béatrice B,Roques
第一单位：
INRA, UMR1331, Toxalim, Research Centre in Food Toxicology, F-31027 Toulouse, France; Université de Toulouse, ENVT, INP, Toxalim, F-31076 Toulouse, France.
作者：
关键词
(13)C(6)-levothyroxine (PubChem CID: 53442260)5′-diphospho (UDP)-glucuronosyltransferaseATP-binding cassetteAbcCARCesConstitutive androstane receptorCypESI(+)FT3FT4FipronilFipronil (PubChem CID: 3352)GABAGEOGOGstHepatic metabolismLOQMRMMRPOATPPBPCNPXRPolr2aPregnane X receptorQCRNA polymerase II polypeptide ART-qPCRRodentsSlcoSultT3T4TATA-box binding proteinTSHTT3TT4TbpThyroid hormone metabolismThyroxine (PubChem CID: 5819)Triiodothyronine (PubChem CID: 5920)Ugtcarboxylesteraseconstitutive androstane receptorcytochrome P450electrospray ionization modefree thyroxinefree triiodothyroninegene expression omnibusgene ontologyglutathione S-transferaselimit of quantificationmultidrug resistance-associated proteinmultiple reaction monitoringorganic anion-transporting polypeptidephenobarbitalpregnane X receptorpregnenolone-16alpha-carbonitrilequality controlreal-time quantitative polymerase chain reactionsolute carrier organic anion transportersulfotransferasethyroid-stimulating hormonethyroxinetotal thyroxinetotal triiodothyroninetriiodothyronineγ-aminobutyric acid
医学主题词
动物(Animals);女(雌)性(Female);基因表达调控(Gene Expression Regulation);肝(Liver);男(雄)性(Male);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);小鼠, 突变型(Mice, Mutant Strains);吡唑类(Pyrazoles);大鼠(Rats);大鼠, Wistar(Rats, Wistar);受体, 胞质和核(Receptors, Cytoplasmic and Nuclear);受体, 类固醇(Receptors, Steroid);种特异性(Species Specificity);甲状腺激素类(Thyroid Hormones)
DOI
10.1016/j.bcp.2013.08.012
PMID
23962444
发布时间
2021-12-03
- 浏览108
Biochemical pharmacology
997-1039页
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