换一批Inhibitors of ROS production by the ubiquinone-binding site of mitochondrial complex I identified by chemical screening.
第一作者：
Adam L,Orr
第一单位：
Buck Institute for Research on Aging, Novato, CA 94945, USA. Electronic address: aorr@buckinstitute.org.
作者：
关键词
AntioxidantCN-POBSComplex IIComplex IIIDMSOEnergy metabolismFCCPFree radicalsGlycerol-3-phosphate dehydrogenaseHydrogen peroxideN-cyclohexyl-4-(4-nitrophenoxy)benzenesulfonamideNADH:Q oxidoreductaseROSRespiratory complexesSuperoxideTMRMTPMPcarbonyl cyanide-4-(trifluoromethoxy)phenylhydrazonedimethyl sulfoxideflavin mononucleotide site of complex Iflavin site of complex IImGPDHmethyltriphenylphosphoniummitochondrial sn-glycerol-3-phosphate dehydrogenaseouter ubiquinone-binding site of complex IIIpH difference across the mitochondrial inner membranepotential difference across the mitochondrial inner membranereactive oxygen speciessite I(F)site I(F) plus matrix NAD-linked dehydrogenasessite I(F)/DHsite I(Q)site II(F)site III(Qo)tetramethylrhodamine methyl esterubiquinone-binding site of complex IΔpHΔΨm
主题词
动物(Animals);结合部位(Binding Sites);电子传递复合物Ⅰ(Electron Transport Complex I);酶抑制剂(Enzyme Inhibitors);女(雌)性(Female);高通量筛选分析(High-Throughput Screening Assays);膜电位, 线粒体(Membrane Potential, Mitochondrial);线粒体, 肌(Mitochondria, Muscle);氧化还原(Oxidation-Reduction);大鼠, Wistar(Rats, Wistar);活性氧(Reactive Oxygen Species);泛醌(Ubiquinone)
DOI
10.1016/j.freeradbiomed.2013.08.170
PMID
23994103
发布时间
2021-10-21
- 浏览12
Free radical biology & medicine
1047-1059页
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