Ochratoxin-induced toxicity, oxidative stress and apoptosis ameliorated by quercetin--modulation by Nrf2.

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作者： Periasamy,Ramyaa ^[1] ; Viswanadha Vijaya,Padma

作者单位： Animal Tissue Culture and Molecular Genetics Laboratory, Department of Biotechnology, School of Biotechnology and Genetic Engineering, Bharathiar University, Coimbatore 641 046, Tamilnadu, India. ^[1]

关键词 2,7-dichlorodihydrofluorescein diacetate 2,7-dichlorofluorescein 3,30-di-hexyloxacarbocyanine iodide 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide ANOVA AO/EB ARE Apoptosis CAT CBMN CCCP DAB DCF DCF-DA DMEM DMSO DNA damage DTT DiOC6 EDTA FBS GPx GSH GST IC20 LDH LPO LPS MN MNBNC MTT NF-κB NO Nrf-2 OPT OTA Ochratoxin Oxidative stress PARP PCC PMSF Quercetin ROS SDS–PAGE SEM SOD Scanning electron microscopy [Ca(2+)](i)acridine orange/ethidium bromide analysis of variance antioxidant responsive element carbonyl cyanide m-chlorophenylhydrazone catalase cytokinesis block micronucleus assay diaminobenzidine dimethyl sulfoxide dithiothreitol dulbecco’s modified eagle’s medium ethylenediamine tetraacetic acid fetal bovine serum glutathione glutathione S transferase glutathione peroxidase iNOS inducible nitric oxide synthase inhibitory concentration 20 intracellular calcium level lactate dehydrogenase lipid peroxidation lipopolysaccharide micronucleated binucleate cells micronucleus nitric oxide nuclear factor E2 p45-related factor 2 nuclear factor-kappa B ochratoxin ortho-phthalaldehyde phenyl methyl sulfonyl fluoride poly (ADP-ribose) polymerase protein carbonyl content reactive oxygen species sodium dodecyl sulfate-polyacrylamide gel electrophoresis superoxide dismutase

主题词动物(Animals);细胞凋亡(Apoptosis);钙(Calcium);DNA碎片裂(DNA Fragmentation);L-乳酸脱氢酶(L-Lactate Dehydrogenase);脂质过氧化作用(Lipid Peroxidation);膜电位, 线粒体(Membrane Potential, Mitochondrial);微核试验(Micronucleus Tests);NF-E2相关因子2(NF-E2-Related Factor 2);一氧化氮(Nitric Oxide);赫曲霉毒素类(Ochratoxins);氧化性应激(Oxidative Stress);预防和防护用药(Protective Agents);蛋白质羟基化(Protein Carbonylation);槲皮素(Quercetin);Vero细胞(Vero Cells)

DOI 10.1016/j.fct.2013.08.048

PMID 23994659

发布时间 2019-12-10

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Food and chemical toxicology

2013年62卷

205-16页

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Ochratoxin-induced toxicity, oxidative stress and apoptosis ameliorated by quercetin--modulation by Nrf2.

Food and chemical toxicology

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Food and chemical toxicology

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Ochratoxin-induced toxicity, oxidative stress and apoptosis ameliorated by quercetin--modulation by Nrf2.

Food and chemical toxicology

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Food and chemical toxicology

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