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首页> Molecular aspects of medicine> The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity.

The molecular etiology and prevention of estrogen-initiated cancers: Ockham's Razor: Pluralitas non est ponenda sine necessitate. Plurality should not be posited without necessity.

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作者： Ercole,Cavalieri ^[1] ; Eleanor,Rogan ^[2]

作者单位： Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198-6805, USA; Department of Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, 984388 Nebraska Medical Center, Omaha, NE 68198-4388, USA. Electronic address: ecavalie@unmc.edu. ^[1] Eppley Institute for Research in Cancer and Allied Diseases, University of Nebraska Medical Center, 986805 Nebraska Medical Center, Omaha, NE 68198-6805, USA; Department of Environmental, Agricultural and Occupational Health, College of Public Health, University of Nebraska Medical Center, 984388 Nebraska Medical Center, Omaha, NE 68198-4388, USA. Electronic address: egrogan@unmc.edu. ^[2]

关键词 1,4-Michael addition mechanism Apurinic sites in DNA Cancer prevention by N-acetylcysteine and resveratrol Carcinogenicity of 4-hydroxyestrogens Cytochrome P4501B1 Depurinating PAH–DNA adducts Depurinating estrogen–DNA adducts Estrogen-3,4-quinones Genotoxicity of estrogens Hormonal carcinogenesis Imbalance of estrogen homeostasis Mutations by error-prone repair Nonhormonal carcinogenesis PAH diol epoxides PAH radical cations Preneoplastic mutations

主题词动物(Animals);致癌物(Carcinogens);细胞色素P450酶系统(Cytochrome P-450 Enzyme System);DNA加合物(DNA Adducts);雌二醇(Estradiol);雌激素类, 儿茶酚(Estrogens, Catechol);雌酮(Estrone);女(雌)性(Female);人类(Humans);男(雄)性(Male);诱变剂(Mutagens);肿瘤(Neoplasms)

DOI 10.1016/j.mam.2013.08.002

PMID 23994691

发布时间 2024-10-01

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Molecular aspects of medicine

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