CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.

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作者： Brian J,Fennell ^[1] ; Barry,McDonnell ^[1] ; Amy Sze Pui,Tam ^[2] ; Lijun,Chang ^[3] ; John,Steven ^[3] ; Ian D,Broadbent ^[3] ; Huilan,Gao ^[2] ; Elizabeth,Kieras ^[4] ; Jennifer,Alley ^[4] ; Deborah,Luxenberg ^[4] ; Jason,Edmonds ^[4] ; Lori J,Fitz ^[4] ; Wenyan,Miao ^[4] ; Matthew J,Whitters ^[4] ; Quintus G,Medley ^[4] ; Yongjing J,Guo ^[2] ; Alfredo,Darmanin-Sheehan ^[1] ; Bénédicte,Autin ^[1] ; Deirdre Ní,Shúilleabháin ^[1] ; Emma,Cummins ^[1] ; Amy,King ^[2] ; Mark R H,Krebs ^[2] ; Christopher,Grace ^[5] ; Timothy P,Hickling ^[5] ; Angela,Boisvert ^[2] ; Xiaotian,Zhong ^[2] ; Matthew,McKenna ^[2] ; Christopher,Francis ^[2] ; Stephane,Olland ^[2] ; Laird,Bloom ^[2] ; Janet,Paulsen ^[2] ; Will,Somers ^[2] ; Allan,Jensen ^[2] ; Laura,Lin ^[2] ; William J J,Finlay ^[1] ; Orla,Cunningham ^[1]

作者单位： Pfizer; Global Biotherapeutics Technologies; Dublin, Ireland. ^[1] Pfizer; Global Biotherapeutics Technologies; Cambridge, MA USA. ^[2] Pfizer; Global Biotherapeutics Technologies, Foresterhill; Aberdeen, UK. ^[3] Pfizer; Immunoscience; Cambridge, MA USA. ^[4] Pfizer; Pharmacokinetics, Dynamics, and Metabolism; Sandwich, UK. ^[5]

关键词 affinity optimization bispecific scFv-Fc-scFv high concentration formulation phage display thermal stability

主题词动物(Animals);抗体, 双特异性(Antibodies, Bispecific);细菌噬菌体(Bacteriophages);互补决定区(Complementarity Determining Regions);酶联免疫吸附测定(Enzyme-Linked Immunosorbent Assay);女(雌)性(Female);人类(Humans);注射, 皮下(Injections, Subcutaneous);肽库(Peptide Library);蛋白质工程(Protein Engineering);蛋白质稳定性(Protein Stability);大鼠(Rats);单链抗体(Single-Chain Antibodies);温度(Temperature)

DOI 10.4161/mabs.26201

PMID 23995618

发布时间 2021-10-21

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CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.

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CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.

mAbs

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mAbs

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