换一批Proteomic profiling of a mouse model of acute intestinal Apc deletion leads to identification of potential novel biomarkers of human colorectal cancer (CRC).
第一作者：
Abeer,Hammoudi
第一单位：
Department of Gastroenterology, Institute of Translational Medicine, The University of Liverpool, Crown Street, Liverpool L69 3GE, UK. Electronic address: abeerwitwit@gmail.com.
作者：
关键词
Adenomatous polyposis coliAhCre(+)Apc(+/+)AhCre(+)Apc(fl)(/)(fl)ApcApc(Min/+)BiomarkersCK18CRCCTBRCCancer Tissue Bank Research CentreColorectal cancerCytokeratin 18DDX5DEAD (Asp-Glu-Ala-Asp) box polypeptide 5ECEFAPFDRHSPD1IHCIPALC MS/MSMMTSNCLNucleolinPCRPHBProhibitinProteomicsROCRPL6Ribosomal protein L6SEMTCEPTEABTFAWBacute conditional transgenic deletion of the Apc gene in the murine intestinal epitheliumadenomatous polyposis coliepithelial cell extractsfalse discovery ratefamilial adenomatous polyposisgFOBtgermline mutations in the Apc gene, spontaneously develop multiple intestinal adenomasguaiac faecal blood testheat shock 60kDa protein 1 (chaperonin)i.p.iTRAQimmunohistochemistryingenuity pathways analysisintra-peritonealisobaric tags for relative and absolute quantificationliquid chromatography–mass spectrometrymethylmethanethiosulfonatepolymerase chain reactionreceiver operating characteristicstandard error of meantriethylammonium bicarbonatetrifluoroacetic acidtris(2-carboxyethyl)phosphinewestern blottingwild type control for acute conditional transgenic deletion of the Apc gene in the murine intestinal epithelium
医学主题词
腺瘤状结肠息肉蛋白质(Adenomatous Polyposis Coli Protein);动物(Animals);结直肠肿瘤(Colorectal Neoplasms);基因缺失(Gene Deletion);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);肠黏膜(Intestinal Mucosa);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);蛋白质组学(Proteomics)
DOI
10.1016/j.bbrc.2013.08.076
PMID
23998936
发布时间
2025-05-29
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