换一批Development of a new in vitro skin sensitization assay (Epidermal Sensitization Assay; EpiSensA) using reconstructed human epidermis.
第一作者：
Kazutoshi,Saito
第一单位：
Kao Corporation, Safety Science Research Laboratories, 2606 Akabane, Ichikai-Machi, Haga-Gun, Tochigi 321-3497, Japan.
作者：
关键词
1-fluoro-2,4-dinitrobenzene2,4-dinitrochlorobenzene2-MBT2-mercaptobenzothiasole4-NBB4-nitrobenzyl bromideACDADHAOOATF3Alternative methodBKCCACYPCinADAVIDDCsDNAJB4DNCBDNFBDatabase for Annotation, Visualization and Integrated DiscoveryECVAMEREpiSensAEpidermal Sensitization AssayEuropean Centre for the Validation of Alternative MethodsGCLMGOGSHGene expressionHSPA6HSPH1IEUILKCsKeratinocytesLALLNAMDBGNMTTMicroarray analysisOXAPPDROSReconstructed human epidermis (RhE) modelRhESASLSSkin sensitizationTMTDTNFacetone: olive oil=4:1activating transcription factor 3alcohol dehydrogenaseallergic contact dermatitisbenzalkonium chloridecinnamic alcoholcinnamic aldehydecytochrome P450dendritic cellsdnaJ (Hsp40) homolog, subfamily B, member 4endoplasmic reticulumgene ontologyglutamate-cysteine ligase, modifier subunitglutathioneheat shock 105kDa/110kDa protein 1heat shock 70kDa protein 6interleukinisoeugenolkeratinocyteslactic acidlocal lymph node assaymethyldibromo glutaronitrilemethylthiazolydiphenyl-tetrazoliumoxazolonep-phenylenediaminereactive oxygen speciesreconstructed human epidermissalicylic acidsodium lauryl sulfatetetramethylthiuram disulfidetumor necrosis factor
医学主题词
变应原(Allergens);动物替代试验(Animal Testing Alternatives);苯扎胺化合物(Benzalkonium Compounds);二硝基氟苯(Dinitrofluorobenzene);表皮(Epidermis);基因表达谱(Gene Expression Profiling);半抗原(Haptens);人类(Humans);寡核苷酸序列分析(Oligonucleotide Array Sequence Analysis);恶唑酮(Oxazolone);皮肤刺激试验(Skin Irritancy Tests)
DOI
10.1016/j.tiv.2013.08.007
PMID
23999411
发布时间
2014-11-20
- 浏览209
Toxicology in vitro
2213-24页
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