换一批
第一作者：
Stanley A,Roberts
第一单位：
SAR Safety Assessment, 14677 Via Bettona, Suite #100 - 432, San Diego, CA 92127, USA. Electronic address: stan@sarsafety.com.
作者：
关键词
ADCADMEAntibody drug conjugatesBiotherapeuticsCytotoxinEFDELISAFIHGLPGood Laboratory PracticeHNSTDICHInternational Conference on HarmonisationLBALC/MS/MSLinkerMSMTDPDPKPayloadRegulatory toxicologySTD(10)Safety assessmentTCRTKV(d)absorption, distribution, metabolism and eliminationantibody-drug conjugateembryofetal developmentenzyme-linked immunosorbent assayfirst-in-humanhERGhighest non-severely toxic dose in non-rodent specieshuman ether-à-go-go related geneligand binding assayliquid chromatography–tandem mass spectrometrymass spectrometrymaximum tolerated dosepharmacodynamicspharmacokineticsseverely toxic dose in 10 of rodentstissue cross-reactivitytoxicokineticsvolume of distribution
医学主题词
动物(Animals);抗体, 单克隆(Antibodies, Monoclonal);抗肿瘤药(Antineoplastic Agents);药物设计(Drug Design);药物评价, 临床前(Drug Evaluation, Preclinical);指导方针(主题)(Guidelines as Topic);人类(Humans);免疫轭合物(Immunoconjugates);研究设计(Research Design);毒性试验(Toxicity Tests)
DOI
10.1016/j.yrtph.2013.08.017
PMID
24012707
发布时间
2013-11-18
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