换一批
换一批Genistein stimulates fatty acid oxidation in a leptin receptor-independent manner through the JAK2-mediated phosphorylation and activation of AMPK in skeletal muscle.
作者：
关键词
0075-amino 4-imidazolecarboxamide ribose5′-adenosine monophosphate-activated protein kinase8-(4-chlorophenylthio)-2-Omethyladenosine-3,5-cAMPACCAICARAMPKCAMKKβCPT1Ca(2+)/calmodulin-dependent protein kinase kinase βEpac1FAOFFAFatty acid oxidationGenisteinHFJAK2Janus kinase 2LEPRObRPDE4PLCPPARαPPARδSCDSIRT1SPSREBP1cSkeletal muscleSoy proteinUCP3acetyl CoA carboxylasecAMP-regulated guanine nucleotide exchange factorcarnitine palmitoyl transferase-1fatty acid oxidationfree fatty acidshigh fatleptin receptorperoxisome proliferator activated receptor-δ PGC-1α, PPAR-γ coactivator-1αperoxisome proliferator-activated receptor-αphosphodiesterasesphospholipase Csirtuin 1soy proteinstearoyl-CoA desaturase-1sterol regulatory element binding protein-1cuncoupling carrier protein 3
主题词
AMP活化蛋白激酶类(AMP-Activated Protein Kinases);动物(Animals);抗致癌药(Anticarcinogenic Agents);细胞系(Cell Line);酶激活(Enzyme Activation);脂肪酸类(Fatty Acids);染料木黄酮(Genistein);Janus激酶2(Janus Kinase 2);男(雄)性(Male);小鼠(Mice);肌纤维, 骨骼(Muscle Fibers, Skeletal);成肌细胞, 骨骼肌(Myoblasts, Skeletal);氧化还原(Oxidation-Reduction);磷酰化(Phosphorylation);大鼠(Rats);大鼠, Zucker(Rats, Zucker);受体, 胞质和核(Receptors, Cytoplasmic and Nuclear);受体, 瘦素(Receptors, Leptin);转录因子(Transcription Factors)
DOI
10.1016/j.bbalip.2013.08.018
PMID
24013029
发布时间
2017-11-16
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