换一批Classifying chemical mode of action using gene networks and machine learning: a case study with the herbicide linuron.
第一作者：
Anna,Ornostay
第一单位：
Department of Biology and Canadian Rivers Institute, University of New Brunswick, Saint John, New Brunswick, E2L 4L5, Canada.
作者：
关键词
17-β estradiol17beta-trenbolone24-dehydrocholesterol reductase5α-dihydrotestosteroneARAXIN1BCL2-like 1BCL2L1BMPRCCSNK1ECTNNB1CYP17A1CYP1B1DHCR24DHTDVL1E(2)EDCsERFABP1FDX1FGF8FHMFLUTFN1FOSFOXOFRAT1FSHBFZDGH1GOGSEAGSK3BGene OntologyGnRHHNF1 homeobox BHNF1BHerbicidesID1IFT88IL16INPP5DJUNLDLRLEFTY2LINLRP6MMP9MOAMYCMachine learningNUCB2Notch signalingPCK2PCRPCSK2POMCParameter of costRBMRadial Basis MachineSEMA3ASHBGSLC5A1SNEASOCS3STATSVMSub-network enrichment analysisSupport Vector MachineTBTFE3TGFBRTHVtgWnt-frizzled pathwayandrogen receptoraxin 1bone morphogenetic protein receptorcasein kinase 1, epsiloncatenin (cadherin-associated protein), beta 1, 88kDacytochrome P450, family 1, subfamily B, polypeptide 1cytochrome P450, family 17, subfamily A, polypeptide 1disheveled, dsh homolog 1 (Drosophila)endocrine disrupting compoundsestrogen receptorfathead minnowfatty acid binding protein 1, liverferredoxin 1fibroblast growth factor 8 (androgen-induced)fibronectin 1flutamidefollicle stimulating hormone, beta polypeptideforkhead box O3frequently rearranged in advanced T-cell lymphomasfrizzled receptorgene set enrichment analysisglycogen synthase kinase 3 betagonadotropin-releasing hormone receptorgrowth hormone 1inhibitor of DNA binding 1, dominant negative helix–loop–helix proteininositol polyphosphate-5-phosphatase, 145kDainterleukin 16 (lymphocyte chemoattractant factor)intraflagellar transport 88 homolog (Chlamydomonas)jun oncogeneleft–right determination factor 2linuronlow density lipoprotein receptorlow density lipoprotein receptor-related protein 6matrix metallopeptidase 9 (gelatinase B,92kDa gelatinase,92kDa type IV collagenase)mode of actionnucleobindin 2phosphoenolpyruvate carboxykinase 2 (mitochondrial)polymerase chain reactionproopiomelanocortinproprotein convertase subtilisin/kexin type 2sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Asex hormone-binding globulinsignal transducer and activator of transcriptionsolute carrier family 5 (sodium/glucose cotransporter), member 1sub-network enrichment analysissuppressor of cytokine signaling 3transcription factor binding to IGHM enhancer 3transforming growth factor, beta receptor 1tyrosine hydroxylasev-fos FBJ murine osteosarcoma viral oncogene homologv-myc myelocytomatosis viral oncogene homolog (avian)vitellogenin
医学主题词
雄激素拮抗药(Androgen Antagonists);动物(Animals);人工智能(Artificial Intelligence);鲤科(Cyprinidae);双氢睾酮(Dihydrotestosterone);内分泌干扰物(Endocrine Disruptors);雌二醇(Estradiol);女(雌)性(Female);氟他胺(Flutamide);基因表达谱(Gene Expression Profiling);基因调控网络(Gene Regulatory Networks);利谷隆(Linuron);卵巢(Ovary);受体, 雄激素(Receptors, Androgen);信号传导(Signal Transduction);水污染物, 化学性(Water Pollutants, Chemical)
DOI
10.1016/j.cbd.2013.08.001
PMID
24013142
发布时间
2015-11-19
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