换一批Folate-modified poly(2-ethyl-2-oxazoline) as hydrophilic corona in polymeric micelles for enhanced intracellular doxorubicin delivery.
第一作者：
Li-Yan,Qiu
第一单位：
College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China.
作者：
关键词
AntitumorBoc-OTsCLSMCMCCROPDOXDoxorubicinFAFRFolic acidN-t-Boc-[2-(p-toluenesulfonyloxy)-ethylamine]PCLPEOzPEOz-PCLTargetingcationic ring opening polymerizationconfocal laser scanning microscopycritical micelle concentrationdoxorubicinfolate receptorfolic acidpoly (2-ethyl-2-oxazoline)poly (?-caprolactone)
医学主题词
动物(Animals);多柔比星(Doxorubicin);药物载体(Drug Carriers);药物释放系统(Drug Delivery Systems);女(雌)性(Female);叶酸(Folic Acid);人类(Humans);亲水和疏水相互作用(Hydrophobic and Hydrophilic Interactions);细胞内液(Intracellular Fluid);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小鼠, 裸(Mice, Nude);微胶粒(Micelles);聚胺类(Polyamines);聚合物(Polymers);随机分配(Random Allocation);异种移植模型抗肿瘤试验(Xenograft Model Antitumor Assays)
DOI
10.1016/j.ijpharm.2013.08.071
PMID
24016742
发布时间
2013-10-16
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