换一批Discovery and characterization of NVP-QAV680, a potent and selective CRTh2 receptor antagonist suitable for clinical testing in allergic diseases.
第一作者：
David A,Sandham
第一单位：
Novartis Institutes for Biomedical Research, Horsham Research Centre, Wimblehurst Road, Horsham, West Sussex RH12 5AB, United Kingdom. Electronic address: david.sandham@novartis.com.
作者：
关键词
13,14-dihydro-15-keto-PGD(2)2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorineAllergyBALBEMPCC chemokine receptor 3CCR-3CRTh2CRTh2 receptor antagonistDK-PGD(2)ELSDFITCGLPPGD(2)SCbronchoalveolar lavagechemoattractant receptor homologous expressed on Th2 cellsevaporative light scattering detectionfluorescein isothiocyanategood laboratory practiceprostaglandin D(2)shape change
医学主题词
投药, 口服(Administration, Oral);动物(Animals);CHO细胞(CHO Cells);仓鼠亚科(Cricetinae);仓鼠属(Cricetulus);皮炎, 接触性(Dermatitis, Contact);疾病模型, 动物(Disease Models, Animal);药物评价, 临床前(Drug Evaluation, Preclinical);嗜酸细胞(Eosinophils);半衰期(Half-Life);人类(Humans);超敏反应(Hypersensitivity);吲哚嗪类(Indolizines);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);蛋白质结合(Protein Binding);大鼠(Rats);大鼠, Sprague-Dawley(Rats, Sprague-Dawley);受体, 免疫(Receptors, Immunologic);受体, 前列腺素(Receptors, Prostaglandin);构效关系(Structure-Activity Relationship);Th2细胞(Th2 Cells)
DOI
10.1016/j.bmc.2013.08.025
PMID
24021582
发布时间
2019-01-15
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