换一批
换一批Anti-neuroinflammatory efficacy of the aldose reductase inhibitor FMHM via phospholipase C/protein kinase C-dependent NF-κB and MAPK pathways.
第一作者：
Ke-Wu,Zeng
第一单位：
State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University Health Science Center, Beijing 100191, PR China.
作者：
关键词
(5-formylfuran-2-yl) methyl 4-hydroxy-2-methylenebutanoateARAldose reductaseFMHMI kappa B kinaseIKKIκBLPSMAPKsMicrogliaNF-κBNeuroinflammationNuclear factor-kappa B (NF-κB)PKCPLCProtein kinase Caldose reductaseinhibitor of kappa Blipopolysaccharidemitogen-activated protein kinasesnuclear factor kappa Bphospholipase Cprotein kinase C
主题词
醛还原酶(Aldehyde Reductase);动物(Animals);消炎药(Anti-Inflammatory Agents);细胞凋亡(Apoptosis);细胞存活(Cell Survival);细胞, 培养的(Cells, Cultured);共同培养技术(Coculture Techniques);减量调节(Down-Regulation);酶抑制剂(Enzyme Inhibitors);I-κB蛋白质类(I-kappa B Proteins);原位缺口末端标记(In Situ Nick-End Labeling);脂多糖类(Lipopolysaccharides);男(雄)性(Male);小鼠(Mice);小鼠, 近交BALB C(Mice, Inbred BALB C);小神经胶质细胞(Microglia);NF-κB(NF-kappa B);一氧化氮(Nitric Oxide);蛋白激酶C(Protein Kinase C);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);信号传导(Signal Transduction);肿瘤坏死因子α(Tumor Necrosis Factor-alpha);C型磷脂酶类(Type C Phospholipases);p38丝裂原活化蛋白激酶类(p38 Mitogen-Activated Protein Kinases)
DOI
10.1016/j.taap.2013.08.028
PMID
24021941
发布时间
2016-11-25
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