换一批
换一批Nitric oxide-releasing prodrug triggers cancer cell death through deregulation of cellular redox balance.
作者：
关键词
ATF, activating transcription factorArylated diazeniumdiolateDAF-FM, 4-amino-5-methylamino-2′,7′-difluorofluorescein diacetateDCF-DA, 5-(and 6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetateDMSO, dimethyl sulfoxideFBS, fetal bovine serumGSH, glutathioneGSSG, glutathione disulfide (oxidized GSH)GlutathioneHBSS, Hank's balanced salt solutionIPA, Ingenuity Pathway AnalysisJS-K, O2-(2,4-dinitrophenyl) 1-[(4-ethoxycarbonyl)piperazin-1-yl]diazen-1-ium-1,2-diolateLC/MS, liquid chromatography/mass spectrometryLeukemiaMAPK, mitogen-activated protein kinaseNAC, N-acetylcysteineNO, nitric oxideNSCLC, non-small cell lung cancerNitric oxidePARP, poly (ADP-ribose) polymeraseRNS, reactive nitrogen speciesROS, reactive oxygen speciesSAPK/JNK, stress activated protein kinase/c-jun N-terminal kinase.
主题词
乙酰半胱氨酸(Acetylcysteine);偶氮化合物(Azo Compounds);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);谷胱甘肽(Glutathione);人类(Humans);白血病(Leukemia);膜电位, 线粒体(Membrane Potential, Mitochondrial);一氧化氮(Nitric Oxide);一氧化氮供体(Nitric Oxide Donors);氧化还原(Oxidation-Reduction);哌嗪类(Piperazines);药物前体(Prodrugs);活性氮(Reactive Nitrogen Species)
DOI
10.1016/j.redox.2012.12.002
PMID
24024144
发布时间
2024-06-15
- 浏览95
Redox biology
2013年1卷
115-24页
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