换一批Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging.
第一作者：
Jenny K,Ngo
第一单位：
Ethel Percy Andrus Gerontology Center of the Davis School of Gerontology, University of Southern California, Los Angeles, CA 90089-0191, USA.
作者：
关键词
2D-PAGE, two-dimensional polyacrylamide gel electrophoresisAAA, ATPases associated with diverse cellular activitiesAco1, Aconitase 1AdaptationCDDO, 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acidCDDO-Me, methyl-2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oateCOX, cytochrome c oxidaseCOX4-1, cytochrome c oxidase subunit IV isoform 1COX4-2, cytochrome c oxidase subunit IV isoform 2Ccp1, mitochondrial cytochrome-c peroxidaseClp, caseinolytic proteaseClpP, core catalytic protease unitERAD, endoplasmic reticulum-associated degradationFRDA, Friedreich's ataxiaFe/S, iron/SULFURHAART, highly active antiretroviral therapyHIF-1, hypoxia inducible factor-1HSP104, heat shock protein 104HSP60, heat shock protein 60HormesisHsIVU, bacterial ATP-dependent proteaseLon ProteaseMELAS, mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodesMPPβ, mitochondrial processing peptidase beta subunitMitochondriaNRF-2, nuclear factor (erythroid-derived 2)-like 2Nfκb, nuclear factor kappa-light-chain-enhancer of activated B csellsOxidative stressPRSS15, LON genePim1, ATP-dependent Lon protease from yeastProtease La, ATP-dependent proteaseProtein degradation and oxidationPrx1, mitochondrial peroxiredoxin 1SLLVY-AMC, N-succinyl-Leu-Leu-Val-Tyr-7-amino-4-methylcoumarinSOD, cytosolic superoxide dismutaseSOD2, mitochondrial superoxide dismutase 2SPG13, hereditary spastic paraplegiaWI-38, human lung fibroblastYjl200c, mitochondrial aconitase isozyme
医学主题词
适应, 生物学(Adaptation, Biological);衰老(Aging);动物(Animals);疾病(Disease);人类(Humans);线粒体(Mitochondria);氧化性应激(Oxidative Stress);蛋白酶La(Protease La);增量调节(Up-Regulation)
DOI
10.1016/j.redox.2013.01.015
PMID
24024159
发布时间
2021-10-21
- 浏览28
Redox biology
2013年1卷
258-64页
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