换一批Effects of 4-hydroxynonenal on vascular endothelial and smooth muscle cell redox signaling and function in health and disease.
第一作者：
Sarah J,Chapple
第一单位：
Cardiovascular Division, British Heart Foundation Centre of Research Excellence, School of Medicine, King's College London, 150 Stamford Street, London SE1 9NH, U.K.
作者：
关键词
15d-PGJ2, 15-deoxy-Delta (12,14) prostaglandin-J24-hydroxynonenalAP-1, Activator protein-1AR, Aldose reductaseARE, Antioxidant response elementATF6, Activating transcription factor 6Akt, Protein kinase BBAEC, Bovine aortic endothelial cellsBH4, TetrahydrobiopterinBLMVEC, Bovine lung microvascular vein endothelial cellsBPAEC, Bovine pulmonary arterial endothelial cellsBTB, Broad complex Tramtrack and Bric–brac domainCHOP, C/EBP-homologous proteinCREB, cAMP response element-binding proteinEGFR, Epidermal growth factor receptorER, Endoplasmic reticulumERAD, Endoplasmic reticulum assisted degradationERK1/2, Extracellular signal-regulated kinase 1/2Elk1, ETS domain-containing proteinEndothelial cellsEpRE, Electrophile response elementFAK, Focal adhesion kinaseFAP, Familial amyloidotic polyneuropathyGCLC, Glutamate cysteine ligase catalytic subunitGCLM, Glutamate cysteine ligase modifier subunitGS-DHN, Glutathionyl-1,4 dihydroxynoneneGS-HNE, HNE-conjugatesGSH, GlutathioneGST, Glutathione-S-transferaseGTPCH, Guanosine triphosphate cyclohydrolase IHASMC, Human aortic smooth muscle cellsHCSMC, Human coronary smooth muscle cellsHERP, Homocysteine inducible ER proteinHMEC, Human microvascular endothelial cellsHNE, 4-hydroxynonenalHO-1, Heme oxygenase-1HUVEC, Human umbilical vein endothelial cellsHsp-70/72/90, Heat shock proteins-70/ -72/ -90IRE1, Inositol requiring enzyme 1 IRE1IVR, Central intervening regionJNK, c-jun N-terminal kinaseKeap1, Kelch-like ECH-associated protein 1MASMC, Mouse aortic smooth muscle cellsMEK1/2, Mitogen activated protein kinase kinase 1/2MMP-1/2, Matrix metalloproteinase-1/ -2MPEC, Mouse pancreatic islet endothelial cellsNAC, N-acetylcysteineNFκB, Nuclear factor kappa BNO, Nitric oxideNQO1, NAD(P)H quinone oxidoreductaseNrf2Nrf2, Nuclear factor-E2-related factor 2PCEC, Porcine cerebral endothelial cellsPDGF, Platelet-derived growth factorPDI, Protein disulfide isomerasesPERK, Protein kinase-like endoplasmic reticulum kinasePKC, Protein kinase CPUFAs, Polyunsaturated fatty acidsRASMC, Rat aortic smooth muscle cellsROS, Reactive oxygen speciesRVSMC, Rat vascular smooth muscle cellsRedox signalingSMC, Smooth muscle cellTKR, Tyrosine kinase receptorUPR, Unfolded protein responseVascular biologyVascular smooth muscle cellseNOS, Endothelial nitric oxide synthaseelF2α, Eukaryotic translation initiation factor 2αiNOS, Inducible nitric oxide synthaseoxLDL, Oxidized low density lipoproteintBHP, Tert-butylhydroperoxidexCT, cystine/glutamate amino acid transporter
医学主题词
醛类(Aldehydes);内质网(Endoplasmic Reticulum);内皮, 血管(Endothelium, Vascular);卫生(Health);人类(Humans);线粒体(Mitochondria);肌, 平滑(Muscle, Smooth);氧化还原(Oxidation-Reduction);信号传导(Signal Transduction)
DOI
10.1016/j.redox.2013.04.001
PMID
24024167
发布时间
2025-05-29
基金项目
PG/13/1/29801/BHF_/British Heart Foundation/United Kingdom
- 浏览40
Redox biology
2013年1卷
319-31页
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