Synergistic re-activation of epigenetically silenced genes by combinatorial inhibition of DNMTs and LSD1 in cancer cells.
第一作者:
Han,Han
第一单位:
Department of Pharmacology and Pharmaceutical Sciences, School of Pharmacy,University of Southern California, Los Angeles, California, United States of America ; Departments of Urology and Biochemistry and Molecular Biology, Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern, California, Los Angeles, California, United States of America.
作者:
主题词
阿扎胞苷(Azacitidine);细胞系, 肿瘤(Cell Line, Tumor);氯吉兰(Clorgyline);DNA甲基化(DNA Methylation);药物协同作用(Drug Synergism);酶抑制剂(Enzyme Inhibitors);基因沉默(Gene Silencing);组蛋白脱甲基酶类(Histone Demethylases);组蛋白类(Histones);人类(Humans);转录激活(Transcriptional Activation);增量调节(Up-Regulation)
DOI
10.1371/journal.pone.0075136
PMID
24040395
发布时间
2021-10-21
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