A diterpenoid compound, excisanin A, inhibits the invasive behavior of breast cancer cells by modulating the integrin β1/FAK/PI3K/AKT/β-catenin signaling.
第一作者:
Juan,Qin
第一单位:
State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University, Guangzhou, China.
作者:
医学主题词
衔接蛋白质类, 信号转导(Adaptor Proteins, Signal Transducing);乳腺肿瘤(Breast Neoplasms);细胞系, 肿瘤(Cell Line, Tumor);细胞运动(Cell Movement);二萜类(Diterpenes);女(雌)性(Female);黏着斑激酶1(Focal Adhesion Kinase 1);人类(Humans);细胞内信号肽和蛋白质类(Intracellular Signaling Peptides and Proteins);膜蛋白质类(Membrane Proteins);肿瘤侵润(Neoplasm Invasiveness);磷酸肌醇3-激酶类(Phosphatidylinositol 3-Kinases);原癌基因蛋白质c-akt(Proto-Oncogene Proteins c-akt);β连环素(beta Catenin)
DOI
10.1016/j.lfs.2013.09.002
PMID
24044886
发布时间
2022-03-16
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Life sciences
655-63页
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