The role of a Schiff base scaffold, N-(2-hydroxy acetophenone) glycinate-in overcoming multidrug resistance in cancer.
第一作者:
Avishek,Ganguly
第一单位:
Department of In Vitro Carcinogenesis and Cellular Chemotherapy, Chittaranjan National Cancer Institute, Kolkata, India.
作者:
关键词
ABC transporterApoptosisCopper N-(2-hydroxyacetophenone)glycinateCuNGDoxorubicin resistant Ehrlich ascites carcinoma cellsEAC/DoxFeNGForkhead box P3FoxP3GSHGlutathioneIron N-(2-hydroxy acetophenone)glycinateMAP kinase signallingMAPKMDRMDSCMRP1Mitogen-activated protein kinaseMultidrug Resistance-associated Protein 1Multidrug resistanceMyeloid derived suppressor cellN-(2-hydroxy acetophenone)glycinateNGROSReactive oxygen speciesSchiff base metal chelatesT regulatory cell (CD4(+)CD25(+)FoxP3(+))T(Reg)TAMTumor-associated macrophageZn N-(2-hydroxyacetophenone)glycinate.ZnNGreactive oxygen species
医学主题词
动物(Animals);螯合剂(Chelating Agents);配位络合物(Coordination Complexes);抗药性, 多药(Drug Resistance, Multiple);抗药性, 肿瘤(Drug Resistance, Neoplasm);人类(Humans);希夫碱类(Schiff Bases)
DOI
10.1016/j.ejps.2013.09.003
PMID
24044945
发布时间
2013-11-18
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