Dysregulation of the epigenome in triple-negative breast cancers: basal-like and claudin-low breast cancers express aberrant DNA hypermethylation.
第一作者:
J Devon,Roll
第一单位:
Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599 USA; UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599 USA. Electronic address: droll@esquaredcommunications.net.
作者:
关键词
Aberrant DNA hypermethylationBasal-like breast cancerClaudin-low breast cancerDNA methyltransferaseDNMTEMTERHER2PRTICTMITriple-negative breast cancerepithelial-to-mesenchymal transitionestrogen receptorgene encoding the epidermal growth factor receptor 2miRmicroRNAprogesterone receptortotal methylation indextumor initiating cell
主题词
乳房(Breast);DNA甲基化(DNA Methylation);表观基因组学(Epigenomics);女(雌)性(Female);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);人类(Humans);肿瘤复发, 局部(Neoplasm Recurrence, Local);预后(Prognosis);启动区, 遗传(Promoter Regions, Genetic);受体, 雌激素(Receptors, Estrogen);受体, 孕酮(Receptors, Progesterone);存活率(Survival Rate)
DOI
10.1016/j.yexmp.2013.09.001
PMID
24045095
发布时间
2021-10-21
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