Stem cell-like ALDH(bright) cellular states in EGFR-mutant non-small cell lung cancer: a novel mechanism of acquired resistance to erlotinib targetable with the natural polyphenol silibinin.
作者:
主题词
醛氧化还原酶类(Aldehyde Oxidoreductases);抗肿瘤药(Antineoplastic Agents);抗氧化剂(Antioxidants);癌, 非小细胞肺(Carcinoma, Non-Small-Cell Lung);细胞周期蛋白质类(Cell Cycle Proteins);抗药性, 肿瘤(Drug Resistance, Neoplasm);基因表达谱(Gene Expression Profiling);基因表达调控, 肿瘤(Gene Expression Regulation, Neoplastic);全基因组关联研究(Genome-Wide Association Study);基因型(Genotype);人类(Humans);肺肿瘤(Lung Neoplasms);突变(Mutation);肿瘤干细胞(Neoplastic Stem Cells);表型(Phenotype);蛋白激酶抑制剂(Protein Kinase Inhibitors);喹唑啉类(Quinazolines);信号传导(Signal Transduction);水飞蓟素(Silymarin);球形体, 细胞(Spheroids, Cellular);肿瘤细胞, 培养的(Tumor Cells, Cultured)
DOI
10.4161/cc.26417
PMID
24047698
发布时间
2022-03-09
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Cell cycle (Georgetown, Tex.)
3390-404页
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