换一批Pharmacokinetics, brain distribution and plasma protein binding of carbamazepine and nine derivatives: new set of data for predictive in silico ADME models.
第一作者：
Ana,Fortuna
第一单位：
Department of Pharmacology, Faculty of Pharmacy, University of Coimbra, Pólo das Ciências da Saúde, Azinhaga de Santa Comba, 3000-548 Coimbra, Portugal; CNC - Centre for Neuroscience and Cell Biology, University of Coimbra, 3004-517 Coimbra, Portugal.
作者：
关键词
10,11-trans-dihydroxy-10,11-dihydro-carbamazepineADMEAEDsAUCAntiepileptic drugsBBBBrainC(max)CBZCBZ-ECNSCarbamazepineDMSOED(50)ESLHPLCISIn silicoLOQMESMRTNSBOXCPPBPharmacokineticsPlasma protein bindingR-LicR-licarbazepineS-LicS-licarbazepineTD(50)UFabsorption distribution metabolism and excretionantiepileptic drugsapparent terminal elimination half-lifearea under the plasma drug concentration–time curveblood–brain barriercarbamazepinecarbamazepine-10,11-epoxidecentral nervous systemdimethyl sulfoxideeffective dose for protecting at 50eslicarbazepine acetatehigh performance liquid chromatographyinternal standardlimit of quantificationlowest median toxic dose at 50maximal electroshock seizuremaximum peak concentrationmean residence timenon-specific bindingoxcarbazepineplasma protein bindingt(1/2)t(max)time to reach maximum peak concentrationtrans-diolultrafiltration
医学主题词
动物(Animals);抗惊厥药(Anticonvulsants);脑(Brain);卡马西平(Carbamazepine);计算机模拟(Computer Simulation);小鼠(Mice);蛋白质结合(Protein Binding);组织分布(Tissue Distribution)
DOI
10.1016/j.eplepsyres.2013.08.013
PMID
24050973
发布时间
2013-11-04
- 浏览121
Epilepsy research
37-50页
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