换一批
换一批Gly161 mutations associated with Primary Hyperoxaluria Type I induce the cytosolic aggregation and the intracellular degradation of the apo-form of alanine:glyoxylate aminotransferase.
作者：
关键词
AGTAlanine:glyoxylate aminotransferaseBS(PEG)5BSACHOChinese hamster ovaryDLSHereditary metabolic diseaseIEMIFMPBSPH1PLPPMPPrimary HyperoxaluriaPrimary Hyperoxaluria Type IProtein aggregationProtein misfoldingPyridoxal phosphateSECalanine:glyoxylate aminotransferasebis-N-succinimidyl-(pentaethylene glycol)esterbovine serum albumindynamic light scatteringimmune electron microscopyimmunofluorescence microscopyphosphate buffered salinepyridoxal 5′-phosphatepyridoxamine 5′-phosphatesize-exclusion chromatography
主题词
动物(Animals);脱辅酶类(Apoenzymes);印迹法, 蛋白质(Blotting, Western);CHO细胞(CHO Cells);细胞, 培养的(Cells, Cultured);色谱法, 凝胶(Chromatography, Gel);仓鼠属(Cricetulus);胞质溶胶(Cytosol);半衰期(Half-Life);人类(Humans);高草酸尿症, 原发性(Hyperoxaluria, Primary);免疫酶技术(Immunoenzyme Techniques);诱变, 定点(Mutagenesis, Site-Directed);突变(Mutation);蛋白质构象(Protein Conformation);蛋白质折叠(Protein Folding);蛋白质多聚化(Protein Multimerization);RNA, 信使(RNA, Messenger);重组蛋白质类(Recombinant Proteins);逆转录聚合酶链反应(Reverse Transcriptase Polymerase Chain Reaction);转氨酶类(Transaminases)
DOI
10.1016/j.bbadis.2013.09.002
PMID
24055001
发布时间
2022-01-29
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