Porphyromonas gingivalis facilitates the development and progression of destructive arthritis through its unique bacterial peptidylarginine deiminase (PAD).
作者:
主题词
动物(Animals);关节炎(Arthritis);自身抗体(Autoantibodies);细菌蛋白质类(Bacterial Proteins);拟杆菌科感染(Bacteroidaceae Infections);骨质吸收(Bone Resorption);瓜氨酸(Citrulline);疾病模型, 动物(Disease Models, Animal);疾病恶化(Disease Progression);基因缺失(Gene Deletion);水解酶类(Hydrolases);关节(Joints);男(雄)性(Male);小鼠, 近交DBA(Mice, Inbred DBA);中性白细胞浸润(Neutrophil Infiltration);牙周炎(Periodontitis);龈紫单胞菌(Porphyromonas gingivalis);中间普里沃菌(Prevotella intermedia);蛋白质加工, 转译后(Protein Processing, Post-Translational);疾病严重程度指数(Severity of Illness Index)
DOI
10.1371/journal.ppat.1003627
PMID
24068934
发布时间
2021-10-21
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PLoS pathogens
e1003627页
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