换一批TRPV4 channel activation leads to endothelium-dependent relaxation mediated by nitric oxide and endothelium-derived hyperpolarizing factor in rat pulmonary artery.
第一作者：
Susanth V,Sukumaran
第一单位：
Division of Pharmacology and Toxicology, Indian Veterinary Research Institute, Izatnagar 243122, Bareilly, Uttar Pradesh, India.
作者：
关键词
1-[(2-chlorophenyl)diphenylmethyl]-1H-pyrazole1H-[1,2,4]oxadiazolo[4,3-a]quinoxalin-1-one4α-PDD4α-phorbol-12,13-didecanoateAChANOVAATPDMSOECsEDHFEETEndotheliumEndothelium-derived hyperpolarizing factorGSKGSK1016790AIK(Ca)L-NAMEMKHSN(G)-nitro-l-arginine methyl esterNONitric oxideODQPCRPEPulmonary arteryRelaxationSK(Ca)SNPTRAM 34TRPV4TRPV4 channelsacetylcholineadenosine triphosphateanalysis of variancedimethyl sulphoxideendothelial cellsendothelium-derived hyperpolarizing factorepoxyeicosatrienoic acidsintermediate conductance potassium channelmodified Krebs–Henseleit solutionnitric oxidephenylephrinepolymerase chain reactionsGCsmall conductance potassium channelsodium nitroprussidesoluble guanylyl cyclasetransient receptor potential vanilloid 4
医学主题词
动物(Animals);生物因子(Biological Factors);内皮, 血管(Endothelium, Vascular);内皮依赖性松弛因子类(Endothelium-Dependent Relaxing Factors);男(雄)性(Male);一氧化氮(Nitric Oxide);肺动脉(Pulmonary Artery);大鼠(Rats);大鼠, Wistar(Rats, Wistar);TRPV阳离子通道(TRPV Cation Channels);血管舒张(Vasodilation)
DOI
10.1016/j.phrs.2013.09.005
PMID
24075884
发布时间
2015-08-31
- 浏览169
Pharmacological research
18-27页
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