换一批Heat shock instructs hESCs to exit from the self-renewal program through negative regulation of OCT4 by SAPK/JNK and HSF1 pathway.
第一作者：
Kyunghee,Byun
第一单位：
Center for Genomics and Proteomics & Stem Cell Core Facility, Lee Gil Ya Cancer and Diabetes Institute, Gachon University, Incheon 406-840, Republic of Korea; Department of Anatomy and Cell Biology, Gachon University Medical School, Incheon 406-840, Republic of Korea.
作者：
关键词
ChIPChromatin-ImmunoprecipitationDAVIDDEGsDMEMDatabase for Annotation, Visualization and Integrated DiscoveryDulbecco's modified Eagle's mediumEBsGO biological processesGOBPsHSFsHSPsKOSRMAPMEFNEAANMFTFsdifferentially expressed genesembryoid bodieshESCsheat shock factorsheat shock proteinshuman embryonic stem cellsknockout serum replacementmESCSmitogen-activated proteinmouse embryonic fibroblast feedermouse embryonic stem cellsnon-essential amino acidnon-negative matrix factorizationsiHSF1siRNA targeting HSF1transcription factors.
医学主题词
细胞分化(Cell Differentiation);DNA结合蛋白质类(DNA-Binding Proteins);胚胎干细胞(Embryonic Stem Cells);基因表达谱(Gene Expression Profiling);基因表达调控(Gene Expression Regulation);人类(Humans);JNK丝裂原活化蛋白激酶类(JNK Mitogen-Activated Protein Kinases);丝裂原活化蛋白激酶8(Mitogen-Activated Protein Kinase 8);八聚体转录因子3(Octamer Transcription Factor-3);磷酰化(Phosphorylation);启动区, 遗传(Promoter Regions, Genetic);蛋白质结合(Protein Binding);RNA干扰(RNA Interference);RNA, 小分子干扰(RNA, Small Interfering);信号传导(Signal Transduction);温度(Temperature);转录因子(Transcription Factors)
DOI
10.1016/j.scr.2013.08.014
PMID
24090933
发布时间
2017-11-16
- 浏览79
Stem cell research
1323-34页
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