Carbonic anhydrase inhibitors. Synthesis of heterocyclic 4-substituted pyridine-3-sulfonamide derivatives and their inhibition of the human cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.

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作者： Jarosław,Sławiński ^[1] ; Krzysztof,Szafrański ; Daniela,Vullo ; Claudiu T,Supuran

作者单位： Department of Organic Chemistry, Medical University of Gdańsk, Al. Gen. J. Hallera 107, 80-416 Gdańsk, Poland. Electronic address: jaroslaw@gumed.edu.pl. ^[1]

关键词 Antitumor activity Carbonic anhydrase isozymes I, II, IX and XII inhibitors Pyridine-3-sulfonamides Synthesis

主题词抗肿瘤药(Antineoplastic Agents);碳酸酐酶抑制剂(Carbonic Anhydrase Inhibitors);碳酸酐酶类(Carbonic Anhydrases);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);剂量效应关系, 药物(Dose-Response Relationship, Drug);药物筛选试验, 抗肿瘤(Drug Screening Assays, Antitumor);杂环化合物(Heterocyclic Compounds);人类(Humans);同工酶类(Isoenzymes);分子结构(Molecular Structure);吡啶类(Pyridines);构效关系(Structure-Activity Relationship);磺胺类(Sulfonamides)

DOI 10.1016/j.ejmech.2013.09.027

PMID 24095761

发布时间 2013-11-04

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European journal of medicinal chemistry

2013年69卷

701-10页

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Carbonic anhydrase inhibitors. Synthesis of heterocyclic 4-substituted pyridine-3-sulfonamide derivatives and their inhibition of the human cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.

European journal of medicinal chemistry

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European journal of medicinal chemistry

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Carbonic anhydrase inhibitors. Synthesis of heterocyclic 4-substituted pyridine-3-sulfonamide derivatives and their inhibition of the human cytosolic isozymes I and II and transmembrane tumor-associated isozymes IX and XII.

European journal of medicinal chemistry

相似文献

European journal of medicinal chemistry

相关期刊

检索历史清除