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首页> Clinical cancer research : an official journal of the American Association for Cancer Research> Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy.

Ang-2-VEGF-A CrossMab, a novel bispecific human IgG1 antibody blocking VEGF-A and Ang-2 functions simultaneously, mediates potent antitumor, antiangiogenic, and antimetastatic efficacy.

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作者： Yvonne,Kienast ^[1] ; Christian,Klein ; Werner,Scheuer ; Romi,Raemsch ; Erica,Lorenzon ; Dirk,Bernicke ; Frank,Herting ; Sidney,Yu ; Huynh Hung,The ; Laurent,Martarello ; Christian,Gassner ; Kay-Gunnar,Stubenrauch ; Kate,Munro ; Hellmut G,Augustin ; Markus,Thomas

作者单位： Authors' Affiliations: Discovery Oncology and Biologics Research, Pharmaceutical Research and Early Development (pRED), Roche Diagnostics GmbH, Penzberg; Department of Vascular Biology and Tumor Angiogenesis, Medical Faculty Mannheim (CBTM), Heidelberg University; Division of Vascular Oncology and Metastasis, German Cancer Research Center Heidelberg (DKFZ-ZMBH Alliance), Heidelberg, Germany; Discovery Oncology, pRED, Roche Glycart AG, Schlieren, Switzerland; Department of Nuclear Medicine, Singapore General Hospital; National Cancer Center, Singapore; Roche Translational Medicine Hub, Singapore; and Roche Products Limited, Welwyn Garden City, United Kingdom. ^[1]

主题词血管生成素2(Angiopoietin-2);动物(Animals);抗体, 双特异性(Antibodies, Bispecific);细胞系, 肿瘤(Cell Line, Tumor);细胞增殖(Cell Proliferation);人类(Humans);免疫球蛋白G(Immunoglobulin G);小鼠(Mice);肿瘤转移(Neoplasm Metastasis);肿瘤(Neoplasms);新生血管化, 病理性(Neovascularization, Pathologic);血管内皮生长因子A(Vascular Endothelial Growth Factor A)

DOI 10.1158/1078-0432.CCR-13-0081

PMID 24097868

发布时间 2015-11-19

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Clinical cancer research : an official journal of the American Association for Cancer Research

Clinical cancer research

2013年19卷24期

6730-40页

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